Perl's config says that U32 access must be aligned.
Checking if your kit is complete...
Looks good
Writing Makefile for Digest::MD5::M4p
cp M4p.pm blib/lib/Digest/MD5/M4p.pm
/Users/cpanrun/pristine/5.8.7/bin/perl /Users/cpanrun/pristine/5.8.7/lib/5.8.7/ExtUtils/xsubpp  -typemap /Users/cpanrun/pristine/5.8.7/lib/5.8.7/ExtUtils/typemap -typemap typemap  M4p.xs > M4p.xsc && mv M4p.xsc M4p.c
gcc -c   -fno-common -DPERL_DARWIN -no-cpp-precomp -arch ppc -arch i386 -nostdinc -B/Developer/SDKs/MacOSX10.4u.sdk/usr/include/gcc -B/Developer/SDKs/MacOSX10.4u.sdk/usr/lib/gcc -isystem/Developer/SDKs/MacOSX10.4u.sdk/usr/include -F/Developer/SDKs/MacOSX10.4u.sdk/System/Library/Frameworks -mmacosx-version-min=10.3 -DUSE_SITECUSTOMIZE -DNO_HASH_SEED -fno-strict-aliasing -pipe -O3   -DVERSION=\"0.01\" -DXS_VERSION=\"0.01\"  "-I/Users/cpanrun/pristine/5.8.7/lib/5.8.7/darwin-thread-multi-2level/CORE"  -DU32_ALIGNMENT_REQUIRED M4p.c
Running Mkbootstrap for Digest::MD5::M4p ()
chmod 644 M4p.bs
rm -f blib/arch/auto/Digest/MD5/M4p/M4p.bundle
LD_RUN_PATH="" env MACOSX_DEPLOYMENT_TARGET=10.3 cc  -bundle -undefined dynamic_lookup -arch ppc -arch i386 -Wl,-search_paths_first -Wl,-syslibroot,/Developer/SDKs/MacOSX10.4u.sdk -mmacosx-version-min=10.3 M4p.o  -o blib/arch/auto/Digest/MD5/M4p/M4p.bundle      
chmod 755 blib/arch/auto/Digest/MD5/M4p/M4p.bundle
cp M4p.bs blib/arch/auto/Digest/MD5/M4p/M4p.bs
chmod 644 blib/arch/auto/Digest/MD5/M4p/M4p.bs
Manifying blib/man3/Digest::MD5::M4p.3
PERL_DL_NONLAZY=1 /Users/cpanrun/pristine/5.8.7/bin/perl "-MExtUtils::Command::MM" "-e" "test_harness(0, 'blib/lib', 'blib/arch')" t/*.t
t/01_test....ok
All tests successful.
Files=1, Tests=7,  0 wallclock secs ( 0.08 cusr +  0.03 csys =  0.11 CPU)
Files found in blib/arch: installing files in blib/lib into architecture dependent library tree
Installing /Users/cpanrun/pristine/5.8.7/man/man3/Digest::MD5::M4p.3
Appending installation info to /Users/cpanrun/pristine/5.8.7/lib/5.8.7/darwin-thread-multi-2level/perllocal.pod
/bin/sh -c true