Checking if your kit is complete...
Looks good
Writing Makefile for Sys::PortIO
cp PortIO.pm blib/lib/Sys/PortIO.pm
AutoSplitting blib/lib/Sys/PortIO.pm (blib/lib/auto/Sys/PortIO)
/Users/cpanrun/pristine/5.8.7/bin/perl /Users/cpanrun/pristine/5.8.7/lib/5.8.7/ExtUtils/xsubpp  -typemap /Users/cpanrun/pristine/5.8.7/lib/5.8.7/ExtUtils/typemap  PortIO.xs > PortIO.xsc && mv PortIO.xsc PortIO.c
Please specify prototyping behavior for PortIO.xs (see perlxs manual)
gcc -c   -fno-common -DPERL_DARWIN -no-cpp-precomp -arch ppc -arch i386 -nostdinc -B/Developer/SDKs/MacOSX10.4u.sdk/usr/include/gcc -B/Developer/SDKs/MacOSX10.4u.sdk/usr/lib/gcc -isystem/Developer/SDKs/MacOSX10.4u.sdk/usr/include -F/Developer/SDKs/MacOSX10.4u.sdk/System/Library/Frameworks -mmacosx-version-min=10.3 -DUSE_SITECUSTOMIZE -DNO_HASH_SEED -fno-strict-aliasing -pipe -O2   -DVERSION=\"0.1\" -DXS_VERSION=\"0.1\"  "-I/Users/cpanrun/pristine/5.8.7/lib/5.8.7/darwin-thread-multi-2level/CORE"   PortIO.c
PortIO.xs:47:20: error: sys/io.h: No such file or directory
PortIO.xs:47:20: error: sys/io.h: No such file or directory
lipo: can't open input file: /var/tmp//ccXnGEq1.out (No such file or directory)
make: *** [PortIO.o] Error 1