Checking if your kit is complete...
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Writing Makefile for Chemistry::OpenBabel
cp OpenBabel.pm blib/lib/Chemistry/OpenBabel.pm
g++ -c  -I../../include -D_POSIX_C_SOURCE=199506L -D_REENTRANT -Ae -D_HPUX_SOURCE -Wl,+vnocompatwarnings +DD64 -DNO_HASH_SEED -D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64 -fast +DSitanium2 +Ofltacc=strict   -DVERSION=\"1.2.0\" -DXS_VERSION=\"1.2.0\" +Z "-I/home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/CORE"   openbabel_perl.cpp
g++: +DD64: No such file or directory
g++: +DSitanium2: No such file or directory
g++: +Ofltacc=strict: No such file or directory
g++: +Z: No such file or directory
cc1plus: error: unrecognized command line option "-fast"
make: *** [openbabel_perl.o] Error 1