Perl's config says that U32 access must be aligned.
Checking if your kit is complete...
Looks good
Warning: prerequisite Digest::base 1.00 not found.
Writing Makefile for Digest::MD5::M4p
cp M4p.pm blib/lib/Digest/MD5/M4p.pm
/home/cpanrun/ia64-lp64/build/5.8.2/bin/perl /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/ExtUtils/xsubpp  -typemap /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/ExtUtils/typemap -typemap typemap  M4p.xs > M4p.xsc && mv M4p.xsc M4p.c
cc -c   -D_POSIX_C_SOURCE=199506L -D_REENTRANT -Ae -D_HPUX_SOURCE -Wl,+vnocompatwarnings +DD64 -DNO_HASH_SEED -D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64 -fast +DSitanium2 +Ofltacc=strict   -DVERSION=\"0.01\" -DXS_VERSION=\"0.01\" +Z "-I/home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/CORE"  -DU32_ALIGNMENT_REQUIRED M4p.c
Warning 863: "M4p.xs", line 529 # Result of operator << is widened from int to long.
     *d++ = base64[(c1 & 0x3) << 4];
                    ^^^^^^^^^^^^^^  
Running Mkbootstrap for Digest::MD5::M4p ()
chmod 644 M4p.bs
rm -f blib/arch/auto/Digest/MD5/M4p/M4p.so
LD_RUN_PATH="" /usr/bin/ld  -b +vnocompatwarnings -L/usr/lib/hpux64 M4p.o  -o blib/arch/auto/Digest/MD5/M4p/M4p.so      
chmod 755 blib/arch/auto/Digest/MD5/M4p/M4p.so
cp M4p.bs blib/arch/auto/Digest/MD5/M4p/M4p.bs
chmod 644 blib/arch/auto/Digest/MD5/M4p/M4p.bs
Manifying blib/man3/Digest::MD5::M4p.3
PERL_DL_NONLAZY=1 /home/cpanrun/ia64-lp64/build/5.8.2/bin/perl "-MExtUtils::Command::MM" "-e" "test_harness(1, 'blib/lib', 'blib/arch')" t/*.t
t/01_test....1..7
ok 1 - use Digest::MD5::M4p;
ok 2 - The object isa Digest::MD5::M4p
ok 3 - Clone
ok 4 - add
ok 5 - nop
ok 6 - add again
ok 7 - and again
ok
All tests successful.
Files=1, Tests=7,  0 wallclock secs ( 0.11 cusr +  0.03 csys =  0.14 CPU)
Installing /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/auto/Digest/MD5/M4p/M4p.so
Installing /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/auto/Digest/MD5/M4p/M4p.bs
Files found in blib/arch: installing files in blib/lib into architecture dependent library tree
Installing /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/Digest/MD5/M4p.pm
Installing /home/cpanrun/ia64-lp64/build/5.8.2/man/man3/Digest::MD5::M4p.3
Appending installation info to /home/cpanrun/ia64-lp64/build/5.8.2/lib/5.8.2/IA64.ARCHREV_0-thread-multi-LP64/perllocal.pod